TY - CHAP M1 - Book, Section TI - Pharmacogenetics and Drug Metabolism A1 - Abraham, Thomas A1 - Adams, Michael A2 - Shargel, Leon A2 - Yu, Andrew B.C. PY - 2016 T2 - Applied Biopharmaceutics & Pharmacokinetics, 7e AB - Define pharmacogenetics and pharmacogenomics.Define genetic polymorphism and explain the difference between genotype and phenotype.Explain with relevant examples how genetic variability influences drug response, pharmacokinetics, and dosing regimen design.Describe the relevance of CYP enzymes and their genetic variability to pharmacokinetics and dosing.List the major drug transporters and describe how their genetic variability can impact pharmacokinetics.Discuss the main issues in applying genomic data to patient care, for example, clinical interpretation of data from various laboratories and accuracy of record keeping of large amounts of genomic data. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1117899508 ER -