TY  - CHAP
M1  - Book, Section
TI  - Physiologic Factors Related to Drug Absorption
A1  - Gerk, Phillip M.
A1  - Yu, Andrew B. C.
A1  - Shargel, Leon
A2  - Shargel, Leon
A2  - Yu, Andrew B.C.
PY  - 2016
T2  - Applied Biopharmaceutics & Pharmacokinetics, 7e
AB  - Define  passive  and  active  drug  absorption.Explain  how  Fick’s  law  of  diffusion  relates  to  passive  drug  absorption.Calculate  the  percent  of  drug  nonionized  and  ionized  for  a  weak  acid  or  weak-base  drug  using  the  Henderson–Hasselbalch  equation,  and  explain  how  this  may  affect  drug  absorption.Define  transcellular  and  paracellular  drug  absorption  and  explain  using  drug  examples.Describe  the  anatomy  and  physiology  of  the  GI  tract  and  explain  how  stomach  emptying  time  and  GI  transit  time  can  alter  the  rate  and  extent  of  drug  absorption.Explain  the  effect  of  food  on  gastrointestinal  physiology  and  systemic  drug  absorption.Describe  the  various  transporters  and  how  they  influence  the  pharmacokinetics  of  drug  disposition  in  the  GI  tract.Explain  the  pH-partition  hypothesis  and  how  gastrointestinal  pH  and  the  pKa  of  a  drug  may  influence  systemic  drug  absorption.  Describe  how  drug  absorption  may  be  affected  by  a  disease  that  causes  changes  in  intestinal  blood  flow  and/or  motility.List  the  major  factors  that  affect  drug  absorption  from  oral  and  nonoral  routes  of  drug  administration.Describe  various  methods  that  may  be  used  to  study  oral  drug  absorption  from  the  gastrointestinal  transit.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/16
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1117899816
ER  -