TY - CHAP
M1 - Book, Section
TI - Empirical Models, Mechanistic Models, Statistical Moments, and Noncompartmental Analysis
A1 - Yue, Corinne Seng
A1 - Ducharme, Murray P.
A2 - Shargel, Leon
A2 - Yu, Andrew B.C.
PY - 2016
T2 - Applied Biopharmaceutics & Pharmacokinetics, 7e
AB - Describe the differences between empirical and mechanistic models.Understand the differences between different types of compartmental analyses.Describe the physiologic pharmacokinetic model with equations and underlying assumptions.List the differences in data analysis between the physiologic pharmacokinetic model, the classical compartmental model, and the noncompartmental approaches.Describe interspecies scaling and its application in pharmacokinetics and toxicokinetics.Describe the statistical moment theory and explain how it provides a unique way to study time-related changes in macroscopic events.Define mean residence time (MRT) and how it can be calculated.Define the mean transit time (MTT) and how it can be used to calculate the mean dissolution time (MDT), or in vivo mean dissolution time, for a solid drug product given orally.Using MRT, derive equations to estimate other pharmacokinetic parameters such as mean absorption time and total volume of distribution.
SN -
PB - McGraw-Hill Education
CY - New York, NY
Y2 - 2020/06/02
UR - accesspharmacy.mhmedical.com/content.aspx?aid=1117903030
ER -