TY - CHAP M1 - Book, Section TI - Opioid Pharmacology A1 - Rollins, Douglas E. A1 - Blumenthal, Donald K. PY - 2016 T2 - Workbook and Casebook for Goodman and Gilman's The Pharmacological Basis of Therapeutics AB - This chapter will be most useful after having a basic understanding of the material in Chapter 18, Opioids, Analgesia, and Pain Management in Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition. In addition to the material presented here, the 12th Edition includes: A history of analgesic useA detailed description of the endogenous opioid systems: ligands and receptorsA discussion of opioid receptor classes, distribution, binding/coupling requirements for opiate ligands, and the functional consequences of acute and chronic opiate receptor activationFigure 18-8 Structures of morphine-related opiate agonists and antagonistsFigure 18-9 Chemical structures of piperidine and phenylpiperidine analgesicsDetails of the cellular and molecular mechanisms of opioid tolerance, dependence, and withdrawalNonanalgesic therapeutic uses of opioidsTable 18-4 Resources for Pain ManagementTable 18-5 World Health Organization Analgesic Ladder SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/25 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1121942637 ER -