TY  - CHAP
M1  - Book, Section
TI  - Carbohydrates: Pentose Phosphate Pathway
A1  - King, Michael W.
PY  - 2014
T2  - Integrative Medical Biochemistry Examination and Board Review
AB  - High-Yield  TermsGlucose-6-phosphate  dehydrogenase  (G6PDH):  primary  rate-limiting,  oxidative  enzyme  of  the  PPP;  mutations  in  this  gene  are  the  most  common  causes  of  hemolytic  anemia  worldwide,  yet  protect  individuals  from  malariaTransketolase:  thiamine-requiring  enzyme,  enzyme  of  the  nonoxidative  stage  of  the  PPP  that  transfers  2-carbon  unitsTransaldolase:  thiamine-requiring  enzyme,  enzyme  of  the  nonoxidative  stage  of  the  PPP  that  transfers  3-carbon  unitsOxygen  burst:  phagocytic  cells  of  the  immune  system  utilize  NADPH  generated  via  the  PPP  to  generate  superoxide  radicals  to  kill  phagocytized  microorganisms.  This  requires  a  dramatic  increase  in  O2  consumption  referred  to  as  the  oxygen  burstChronic  granulomatous  disease:  results  in  individuals  harboring  defects  in  the  NADPH  oxidase  system  of  phagocytic  cells,  results  in  frequent  pneumonia,  abscesses  of  the  skin,  tissues,  and  organs,  suppurative  arthritis,  and  osteomyelitis.  Defects  occur  in  both  the  NADPH  oxidase  complex  itself  and  the  enzymes  of  the  PPP  that  yield  the  required  NADPH,  particularly  G6PDH  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1122103566
ER  -