TY  - CHAP
M1  - Book, Section
TI  - Nitrogen: Amino Acid Metabolism
A1  - King, Michael W.
PY  - 2014
T2  - Integrative Medical Biochemistry Examination and Board Review
AB  - High-Yield  TermsGlucogenic:  relating  to  amino  acids  whose  catabolic  products  can  be  used  for  net  glucose  synthesis  during  gluconeogenesisKetogenic:  relating  to  amino  acids  whose  catabolic  products  enter  the  tricarboxylic  acid  (TCA)  cycle  but  cannot  be  used  for  net  glucose  synthesis  during  gluconeogenesisEssential  amino  acid:  any  amino  acid  that  cannot  be  formed  de  novo  or  from  other  precursor  compounds  within  mammalian  cellsGlutamate  dehydrogenase:  critical  enzyme  catalyzing  the  interconversion  of  glutamate  and  α-ketoglutarate,  serves  as  a  gateway  reaction  between  cellular  energy  demands  and  nitrogen  homeostasisAsparaginase:  enzyme  catalyzing  the  deamination  of  asparagine  to  aspartate,  enzyme  is  used  clinically  as  a  chemotherapeutic  treatment  for  certain  leukemiasCystathionine  β-synthase:  enzyme  involved  in  cysteine  biosynthesis,  deficiencies  are  most  common  cause  of  homocystinuriasGlycine  cleavage  complex:  also  called  glycine  decarboxylase,  enzyme-catabolizing  glycine,  defects  in  activity  cause  glycine  encephalopathyPhenylketonuria  (PKU):  a  particular  form  of  hyperphenylalaninemia  resulting  from  defects  in  the  phenylalanine  hydroxylase  geneBranched-chain  amino  acid:  consists  of  leucine,  isoleucine,  and  lysine;  defects  in  the  catabolic  enzyme  branched-chain  keto  acid  dehydrogenase  (BCKD)  result  in  Maple  syrup  urine  disease  (MSUD)Alkaptonuria:  first  inherited  error  in  metabolism  to  be  characterized,  benign  disease  caused  by  defects  in  the  tyrosine-catabolizing  enzyme  homogentisate  oxidase,  urine  of  afflicted  patients  turns  brown  on  exposure  to  air  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1122104375
ER  -