TY - CHAP M1 - Book, Section TI - Hemostasis: Blood Coagulation A1 - King, Michael W. PY - 2014 T2 - Integrative Medical Biochemistry Examination and Board Review AB - High-Yield TermsHemostasis: refers to the process of blood clotting and then the subsequent dissolution of the clot following repair of the injured tissueIntrinsic pathway: pathway of coagulation initiated in response to contact of blood with a negatively charged surface; primarily represents a pathophysiological reactionExtrinsic pathway: pathway of coagulation initiated in response to release of tissue factor in response to vascular injury; represents the normal physiological pathway of coagulationPlatelets: also called thrombocytes; are small, disk-shaped nonnucleated fragments released from megakaryocytes involved in initiating hemostasisPlatelet glycoproteins: refers to several types of platelet surface receptors (eg, GPIIb-GPIIIa) involved in the processes of platelet activation and aggregationKallikrein: any of several serine proteases that cleave kininogens to form kinins; includes plasma and tissue kallikreinsKinin: any of a group of vasoactive polypeptides (eg, bradykinin) formed by kallikrein-catalyzed cleavage of kininogens causing vasodilation and altering vascular permeabilityTenase complex: the complex of calcium ions and factors VIIIa, IXa, and X on the surface of activated plateletsProthrombinase complex: a complex composed of platelet phospholipids, calcium ions, factors Va and Xa, and prothrombinThrombus: refers to the blood clot which is the final product of the blood coagulationvon Willebrand factor, vWF: a complex multimeric glycoprotein that is produced by and stored in the α-granules of platelets and found associated with subendothelial connective tissue.Factor V Leiden: an inherited disorder of blood clotting resulting from a variant factor V that causes a hypercoagulability disorderPartial thromboplastin time (PTT): assay for defects in activities of the intrinsic pathway of coagulationProthrombin time (PT): assay for defects in activities of the extrinsic pathway of coagulation SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1122105876 ER -