TY - CHAP M1 - Book, Section TI - Nucleophilic Substitution, Addition, and Elimination Reactions A1 - Li, Jie Jack A1 - Renslo, Adam A2 - Renslo, Adam PY - 2016 T2 - The Organic Chemistry of Medicinal Agents AB - The first few chapters of this text were focused on important properties of organic molecules and how these help determine the nature of a drug’s interaction with its biological target. In this chapter and the ones that follow, we will discuss certain reactions of drug molecules and enzymes – biological macromolecules that break and form chemical bonds. In this chapter we discuss substitution, addition, and elimination reactions. The main focus is on substitution reactions, which are prevalent in physiological and metabolic processes, in the action of some drugs, and in the chemical synthesis of nearly all drugs. The topic of addition reactions is introduced here and expanded upon in the following chapter on carbonyl chemistry. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1124842712 ER -