TY - CHAP M1 - Book, Section TI - Sepsis and Septic Shock A1 - Kang-Birken, S. Lena A2 - DiPiro, Joseph T. A2 - Talbert, Robert L. A2 - Yee, Gary C. A2 - Matzke, Gary R. A2 - Wells, Barbara G. A2 - Posey, L. Michael PY - 2017 T2 - Pharmacotherapy: A Pathophysiologic Approach, 10e AB - Content UpdateOctober 31, 2017Lower Mortality with Rapid Completion of 3-hour Sepsis Bundle: Inappropriate antimicrobial selection and delays in initiating therapy are associated with increased mortality in patients with sepsis. Sepsis "bundles" and practice guidelines are associated with reduced mortality in sepsis patients. A recent publication involving more than 40,000 patients with sepsis and septic shock at 149 New York hospitals reported on a sepsis protocol initiated within 6 hours of arrival that included a 3-hour bundle of care (blood cultures, broad-spectrum antibiotics, and lactate measurement). Risk-adjusted in-hospital mortality was higher in patients when the sepsis bundle was completed in 12 hours vs. the goal of within 3 hours. Longer time to administration of antibiotics was also associated with higher in-hospital mortality. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/14 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1148444821 ER -