TY - CHAP M1 - Book, Section TI - Drug-Induced Kidney Disease A1 - Nolin, Thomas D. A2 - DiPiro, Joseph T. A2 - Talbert, Robert L. A2 - Yee, Gary C. A2 - Matzke, Gary R. A2 - Wells, Barbara G. A2 - Posey, L. Michael PY - 2017 T2 - Pharmacotherapy: A Pathophysiologic Approach, 10e AB - Content UpdateAugust 7, 2018Nephrotoxic Potential of Novel Anticancer Immunotherapies: Several novel anticancer immunotherapies have been associated with development of nephrotoxicity - the checkpoint inhibitors (CPIs) ipilimumab, pembrolizumab, and nivolumab and the chimeric antigen receptor therapy (CAR-T) products tisagenlecleucel and axicabtagene ciloleucel. Acute kidney injury (AKI) may occur 3 to 16 months after CPI exposure, which makes extended renal function monitoring critical for detection and treatment. CAR-T is associated with cytokine release syndrome, tumor lysis syndrome, and electrolyte abnormalities. Given the increasing use of these novel agents, collaboration among oncologists, nephrologists, pharmacists, and other clinicians is vital to ensure appropriate agent-specific monitoring and management of renal adverse effects while maintaining maximum anticancer efficacy. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1155626473 ER -