TY - CHAP M1 - Book, Section TI - Laboratory Tests to Direct Antimicrobial Pharmacotherapy A1 - Rybak, Michael J. A1 - Aeschlimann, Jeffrey R. A1 - LaPlante, Kerry L. A2 - DiPiro, Joseph T. A2 - Talbert, Robert L. A2 - Yee, Gary C. A2 - Matzke, Gary R. A2 - Wells, Barbara G. A2 - Posey, L. Michael PY - 2017 T2 - Pharmacotherapy: A Pathophysiologic Approach, 10e AB - Content UpdateJuly 12, 2017Using Cystatin C to Guide Vancomycin Dosing: Cystatin C is a renal biomarker that has been proposed to be used as an alternative to or in conjunction with creatinine for estimating glomerular filtration rate (GFR). Two recent studies employed a practical approach to development and implementation of a cystatin C-inclusive vancomycin dosing nomogram in clinical practice. The authors developed a dosing nomogram that used CKD-EPIcreatinine-cystatinC based estimated GFR (eGFRcr-cysC) as well as the target vancomycin trough level and patient weight. The authors then conducted a QI project to evaluate the routine use of this nomogram in critically-ill patients. Use of the CKD-EPIcreatinine-cystatinC equation to estimate GFR for vancomycin dosing was shown to be feasible and was associated with a clinically and statistically significant increase in target vancomycin trough achievement. Additional prospective research is warranted. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1145264766 ER -