TY  - CHAP
M1  - Book, Section
TI  - Drug-Induced Liver Disease
A1  - Wells, Barbara G.
A1  - DiPiro, Joseph T.
A1  - Schwinghammer, Terry L.
A1  - DiPiro, Cecily V.
PY  - 2017
T2  - Pharmacotherapy Quick Guide
AB  - Table  Graphic  Jump  Location|Download  (.pdf)|PrintTABLE  A4–1:  An  Approach  to  Evaluating  a  Suspected  Hepatotoxic  ReactionPoints–3–10+1+2+3What  is  the  temporal  relationship?  (days)From  the  start  of  therapy——??905–90From  the  end  of  therapy>30—??——<30Is  there  evidence  of  the  concurrent  use  of  a  hepatotoxina?YesMaybe??——NoIs  there  an  alternate  cause,  such  as  viral  hepatitis?YesMost  likely—Yes??Most  likely—No  NoAre  there  extrahepatic  signs  or  symptoms?Dermatologic:  rash,  palmar  erythema,  cutaneous  vasculitis——NoYes  (+1  for  each)——Dermatologic:  spider  nevi,  white  nails  (aka  Terry’s  nails)——NoYes  (+1  for  each)——Hematologic:  coagulation  disorders——NoYes  (+1  for  each)——Endocrine:  insulin  resistance,  thyroid  dysfunction——NoYes  (+1  for  each)——Endocrine:  adrenal  insufficiency,  hypogonadism——NoYes  (+1  for  each)——Skeletal  muscular:  arthralgias,  arthritis——NoYes  (+1  for  each)——Neurologic:  encephalopathy——NoYes  (+1  for  each)——Portopulmonary  hypertension——NoYes  (+1  for  each)——Does  the  literature  support  a  connection  with  this  drug?Listed  in  the  product  labeling—————YesPublished  reports  in  the  literature————Yes—No  information  available,  reaction  is  undocumented——Yes———Results  from  a  rechallenge  with  the  drugNegative——Inconclusive—Positive(??,  Uncertain.)A  total  score  <7  makes  it  unlikely  that  this  is  a  hepatotoxic  reaction.As  the  score  approaches  14;  the  possibility  that  this  is  a  hepatotoxic  reaction  increases  toward  certainty.aDrug,  herbal  remedy,  or  other  occupational  exposure  known  to  be  potentially  hepatotoxic.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/24
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1144733285
ER  -