TY  - CHAP
M1  - Book, Section
TI  - Therapeutic & Toxic Potential of Over-the-Counter Agents
A1  - Clinard, Valerie B.
A1  - Corelli, Robin L.
A2  - Katzung, Bertram G.
PY  - 2017
T2  - Basic & Clinical Pharmacology, 14e
AB  - CASE  STUDYKH,  a  55-year-old  woman,  presents  to  the  emergency  department  with  nausea,  vomiting,  and  complaints  of  new-onset  flu  symptoms  over  the  past  several  days.  Her  past  medical  history  is  significant  for  allergic  rhinitis  and  chronic  lower  back  pain  secondary  to  a  work-related  fall  2  years  ago.  Her  current  medications  include  Norco  5/325  (hydrocodone  5  mg/acetaminophen  325  mg  per  tablet;  two  tablets  four  times  daily  for  pain)  and  loratadine  (10  mg  daily).  The  patient  also  reported  recent  use  of  several  over-the-counter  (OTC)  medications  over  the  past  3  days  to  treat  the  new-onset  flu  symptoms,  including  Alka-Seltzer  Plus  Severe  Cold  +  Flu  (two  tablets  every  4  hours  during  the  day)  and  Tylenol  PM  (two  tablets  at  bedtime).  Her  social  history  is  significant  for  alcohol  use  (three  to  four  glasses  of  wine/night).  Her  vital  signs  include  the  following:  temperature  99.8°F,  blood  pressure  132/64  mm  Hg,  pulse  78  bpm,  and  respiratory  rate  15/min.  On  physical  examination,  she  had  left  upper  abdominal  tenderness  with  evidence  of  hepatomegaly  and  mild  scleral  icterus.  Laboratory  data  revealed  the  following:  alanine  aminotransferase,  527  IU/L  (normal  10–35  IU/L);  aspartate  aminotransferase,  425  IU/L  (normal  <  35  IU/L);  and  bilirubin,  2.9  mg/dL  (normal  0.1–0.3  mg/dL).  What  medications  do  OTC  cold  and  flu  preparations  typically  contain?  Which  of  the  OTC  medications  might  have  contributed  to  the  patient’s  current  symptoms?  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1148443261
ER  -