TY - CHAP M1 - Book, Section TI - Hormone Action & Signal Transduction A1 - Weil, P. Anthony A2 - Rodwell, Victor W. A2 - Bender, David A. A2 - Botham, Kathleen M. A2 - Kennelly, Peter J. A2 - Weil, P. Anthony PY - 2018 T2 - Harper's Illustrated Biochemistry, 31e AB - OBJECTIVESAfter studying this chapter, you should be able to:Explain the roles of stimulus, hormone release, signal generation, and effector response in hormone-regulated physiologic processes.Describe the role of receptors and guanosine nucleotide-binding G-proteins in hormone signal transduction, particularly with regard to the generation of second messengers.Appreciate the complex patterns of signal transduction pathway cross-talk in mediating complicated physiologic outputs.Understand the key roles that protein-ligand, protein–protein, protein posttranslational modification, and protein-DNA interactions play in mediating hormone-directed physiologic processes.Detail why hormone-modulated receptors, second messengers, and associated signaling molecules represent a rich source of potential drug target development given their key roles in the regulation of physiology. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1160191772 ER -