TY  - CHAP
M1  - Book, Section
TI  - Alcoholic Liver Disease
A1  - Mailliard, Mark E.
A1  - Sorrell, Michael F.
A2  - Jameson, J. Larry
A2  - Fauci, Anthony S.
A2  - Kasper, Dennis L.
A2  - Hauser, Stephen L.
A2  - Longo, Dan L.
A2  - Loscalzo, Joseph
PY  - 2018
T2  - Harrison's Principles of Internal Medicine, 20e
AB  - Chronic  and  excessive  alcohol  ingestion  is  a  major  cause  of  liver  disease  and  is  responsible  for  nearly  50%  of  the  mortality  from  all  cirrhosis.  The  pathology  of  alcoholic  liver  disease  consists  of  three  major  lesions,  with  the  progressive  injury  rarely  existing  in  a  pure  form:  (1)  fatty  liver,  (2)  alcoholic  hepatitis,  and  (3)  cirrhosis.  Fatty  liver  is  present  in  >90%  of  daily  as  well  as  binge  drinkers.  A  much  smaller  percentage  of  heavy  drinkers  will  progress  to  alcoholic  hepatitis,  thought  to  be  a  precursor  to  cirrhosis.  The  prognosis  of  severe  alcoholic  liver  disease  is  dismal;  the  mortality  of  patients  with  alcoholic  hepatitis  concurrent  with  cirrhosis  is  nearly  60%  at  4  years.  Although  alcohol  is  considered  a  direct  hepatotoxin,  only  between  10  and  20%  of  alcoholics  will  develop  alcoholic  hepatitis.  The  explanation  for  this  apparent  paradox  is  unclear  but  involves  the  complex  interaction  of  facilitating  factors  such  as  drinking  patterns,  diet,  obesity,  and  gender.  There  are  no  diagnostic  tools  that  can  predict  individual  susceptibility  to  alcoholic  liver  disease.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/17
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1156507565
ER  -