TY - CHAP M1 - Book, Section TI - Human Immunodeficiency Virus A1 - Bookstaver, P. Brandon A2 - Sutton, S. Scott PY - 2019 T2 - McGraw-Hill's NAPLEX® Review Guide, 3e AB - The human immunodeficiency virus (HIV or HIV-1) is a retrovirus that causes the acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune system leads to life-threatening opportunistic infections. A second retrovirus, HIV-2, also is recognized to cause AIDS, although it is less virulent, transmissible, and prevalent than HIV-1. Modern antiretroviral regimens have decreased the morbidity and mortality of HIV; however, HIV infection cannot be cured due to the integration of the HIV genome into host cells, creating a latent reservoir. An AIDS diagnosis is made when the presence of HIV is laboratory-confirmed and the cluster of differentiation 4 (CD4 cell) count drops below 200 cells/mm3 (200 × 106/L) for those older than or equal to 6 years of age or after the development of an opportunistic infection. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1158314605 ER -