TY - CHAP M1 - Book, Section TI - Toxicokinetics A1 - Krishnan, Kannan A2 - Klaassen, Curtis D. PY - 2019 T2 - Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th edition AB - Toxicokinetics refers to the quantitative study of absorption, distribution, metabolism, and excretion (ADME) of chemicals in biota through measurement and modeling of their concentrations or amounts in biological matrices (e.g., blood, plasma, excreta, exhaled air, tissues) as a function of time. Experimental studies of toxicokinetics facilitate the characterization of the temporal profile of the concentration of chemicals and their metabolites in the target tissue or other biological matrices, reflective of the net effect of the rate and extent of absorption through one or more exposure routes, distribution to tissues and organs via systemic circulation as well as disposition by metabolism and excretion (Fig. 7-1). The experimental and quantitative approaches used today for characterizing toxicokinetics of xenobiotics were derived from such studies extensively conducted with drugs over the past decades (traditionally known as pharmacokinetics) (Gibaldi and Perrier, 1975, 1982; O'Flaherty, 1981; WHO, 1986; Rescigno, 1997; Tozer and Rowland, 2006). Toxicokinetic data and analyses constitute an essential part of systematic approaches to safety/risk evaluation of xenobiotics and other substances including therapeutic drugs. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1158497449 ER -