TY - CHAP M1 - Book, Section TI - Normal Human Microbiota A1 - Riedel, Stefan A1 - Hobden, Jeffery A. A1 - Miller, Steve A1 - Morse, Stephen A. A1 - Mietzner, Timothy A. A1 - Detrick, Barbara A1 - Mitchell, Thomas G. A1 - Sakanari, Judy A. A1 - Hotez, Peter A1 - Mejia, Rojelio PY - 2019 T2 - Jawetz, Melnick, & Adelberg's Medical Microbiology, 28e AB - The term “normal microbial flora” denotes the population of microorganisms that inhabit the skin and mucous membranes of healthy normal persons. Previous estimates suggested that the microorganisms that live inside and on humans (now referred to as the normal microbiota) outnumber human somatic and germ cells by a factor of 10. More recent estimates indicate the ratio is much closer to 1:1. The genomes of these microbial symbionts are collectively defined as the microbiome. Research has shown that the “normal microbiota” provides a first line of defense against microbial pathogens, assists in digestion, plays a role in toxin degradation, and contributes to maturation of the immune system. Shifts in the normal microbiota or stimulation of inflammation by these commensals may cause diseases such as bacterial vaginosis, periodontitis, and inflammatory bowel disease. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/16 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1163279181 ER -