TY  - CHAP
M1  - Book, Section
TI  - Infections in Prosthetic Joints
A1  - Madoff, Lawrence C.
A2  - Jameson, J. Larry
A2  - Fauci, Anthony S.
A2  - Kasper, Dennis L.
A2  - Hauser, Stephen L.
A2  - Longo, Dan L.
A2  - Loscalzo, Joseph
PY  - 2018
T2  - Harrison's Principles of Internal Medicine, 20e
AB  - Infection  complicates  1–4%  of  total  joint  replacements.  The  majority  of  infections  are  acquired  intraoperatively  or  immediately  postoperatively  as  a  result  of  wound  breakdown  or  infection;  less  commonly,  these  joint  infections  develop  later  after  joint  replacement  and  are  the  result  of  hematogenous  spread  or  direct  inoculation.  The  presentation  may  be  acute,  with  fever,  pain,  and  local  signs  of  inflammation,  especially  in  infections  due  to  S.  aureus,  pyogenic  streptococci,  and  enteric  bacilli.  Alternatively,  infection  may  persist  for  months  or  years  without  causing  constitutional  symptoms  when  less  virulent  organisms,  such  as  coagulase-negative  staphylococci  or  diphtheroids,  are  involved.  Such  indolent  infections  usually  are  acquired  during  joint  implantation  and  are  discovered  during  evaluation  of  chronic  unexplained  pain  or  after  a  radiograph  shows  loosening  of  the  prosthesis;  the  erythrocyte  sedimentation  rate  and  C-reactive  protein  level  are  usually  elevated  in  such  cases.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/24
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1177742396
ER  -