TY - CHAP M1 - Book, Section TI - Toxic Effects of Metals A1 - Ufelle, Alexander C. A1 - Barchowsky, Aaron A2 - Klaassen, Curtis D. A2 - Watkins, John B. PY - 2021 T2 - Casarett & Doull’s Essentials of Toxicology, 4e AB - KEY POINTSPersons at either end of the life span, young children or elderly people, are more susceptible to toxicity from exposure to a particular level of metal than most adults.Metals that provoke immune reactions include mercury, gold, platinum, beryllium, chromium, and nickel.Complexation is the formation of a metal ion complex in which the metal ion is associated with a charged or uncharged electron donor, referred to as a ligand.Chelation occurs when bidentate ligands form ring structures that include the metal ion and the two ligand atoms attached to the metal.Metal–protein interactions include binding to numerous enzymes, the metallothioneins, nonspecific binding to proteins such as serum albumin or hemoglobin, and specific metal carrier proteins involved in the membrane transport of metals. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1178016466 ER -