TY - CHAP M1 - Book, Section TI - Acute Kidney Injury A1 - Schwinghammer, Terry L. A1 - DiPiro, Joseph T. A1 - Ellingrod, Vicki L. A1 - DiPiro, Cecily V. PY - 2021 T2 - Pharmacotherapy Handbook, 11e AB - Acute kidney injury (AKI) is a clinical syndrome generally defined by an abrupt reduction in kidney function as evidenced by changes in serum creatinine (Scr), blood urea nitrogen (BUN), and urine output.RIFLE (Risk, Injury, Failure, Loss of Kidney Function, and End-Stage Renal Disease), AKIN (Acute Kidney Injury Network), and the Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guidelines are three criteria-based classification systems developed to define and stage AKI in different patient populations (Table 74-1).All three staging systems have been validated across different patient populations, and their staging correlates closely with hospital mortality, cost, and length of stay.Scr and urine output are the main diagnostic criteria for each staging system. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/04/19 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1178898838 ER -