TY - CHAP M1 - Book, Section TI - Lung Cancer A1 - Hecht, Keith A. A2 - Sutton, S. Scott PY - 2020 T2 - McGraw Hill’s NAPLEX® Review Guide, 4e AB - Lung carcinomas arise from normal bronchial cells that have acquired multiple genetic lesions and are capable of expressing a variety of phenotypes. There are four major subtypes of lung cancer: small cell, squamous cell, adenocarcinoma, and large cell. Squamous cell, adenocarcinoma, and large cell are collectively referred to as non–small-cell lung cancer (NSCLC). NSCLC represents 85% of the lung cancer diagnoses while the aggressive histology small-cell lung cancer (SCLC) represents 15% of lung cancer diagnoses. Adenocarcinoma is the most common histology of NSCLC (50% of all lung cancer) and is associated with a high incidence of distant metastasis at diagnosis. Squamous cell is the second most common histology of NSCLC (30% of all lung cancer) followed by large cell. Adenocarcinoma and large-cell lung cancer generally present as peripheral lesions in the lung, whereas squamous cell and small cell histologies commonly present as central lesions, often causing hemoptysis or postobstructive pneumonia. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1179733478 ER -