TY  - CHAP
M1  - Book, Section
TI  - Breast Cancer
A1  - Sylvester, Robert K.
A1  - Narveson, Lisa
A2  - Sutton, S. Scott
PY  - 2020
T2  - McGraw Hill’s NAPLEX® Review Guide, 4e
AB  - Mutations  of  genes  controlling  cell  proliferation  and  apoptosis  are  the  primary  cause  of  neoplastic  disease  and  specific  gene  mutations  (BRCA1,  BRCA2,  p53,  PTEN)  have  been  identified  in  breast  cancer.  Women  with  mutations  in  the  tumor  suppressor  genes  BRCA1  and  BRCA2  have  a  four-  to  fivefold  increased  risk  for  the  development  of  breast  cancer  (approximate  lifetime  risk  increases  from  12%  to  45%-65%).  In  addition,  family  history,  prolonged  exposure  to  estrogen  (early  menarche,  nulliparity,  late  first  pregnancy,  late  menopause)  and  age  over  40  have  been  established  as  risk  factors  for  breast  cancer.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1179733677
ER  -