TY - CHAP M1 - Book, Section TI - Targeted Drug Delivery Systems and Biotechnology Products A1 - Dhaval K., Shah A1 - Zhe, Li A1 - Donald E., Mager A2 - Ducharme, Murray P. A2 - Shargel, Leon PY - 2022 T2 - Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, 8e AB - Describe basic classification categories of protein therapeutics and discuss example drugs in each group.Compare and contrast the general pharmacokinetic characteristics of small-molecule and biological drugs.Describe the unique targeting mechanisms of monoclonal antibodies and novel antibody-based constructs along with general determinants of their disposition and effects.Identify the need and rationale for drug carriers and formulations for biologics along with the major components of targeted drug delivery systems.Recognize integrating and non-integrating delivery vectors that address disposition challenges and enable effective gene therapies.Describe the major processes governing the pharmacokinetic properties of biopharmaceuticals. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/20 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1188767572 ER -