TY - CHAP M1 - Book, Section TI - Chapter 11. Toxic Responses of the Blood A1 - Bloom, John C. A1 - Brandt, John T. A2 - Klaassen, Curtis D. A2 - Watkins, John B. PY - 2010 T2 - Casarett & Doull's Essentials of Toxicology, 2e AB - Hematotoxicology is the study of adverse effects of exogenous chemicals on blood and blood-forming tissues.Direct or indirect damage to blood cells and their precursors includes tissue hypoxia, hemorrhage, and infection.Xenobiotic-induced aplastic anemia is a life-threatening disorder characterized by peripheral blood pancytopenia, reticulocytopenia, and bone marrow hypoplasia.Idiosyncratic xenobiotic-induced agranulocytosis may involve a sudden depletion of circulating neutrophils concomitant with exposure that persists as long as the agent or its metabolites are in the circulation.Leukemias are proliferative disorders of hematopoietic tissue that originate from individual bone marrow cells.Xenobiotic-induced thrombocytopenia may result from increased platelet destruction or decreased platelet production, which lead to decreased platelet aggregation and bleeding disorders.Blood coagulation is a complex process involving a number of proteins whose synthesis and function can be altered by many xenobiotics. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=6481806 ER -