TY - CHAP M1 - Book, Section TI - Chapter 19. Toxic Responses of the Skin A1 - Rice, Robert H. A1 - Mauro, Theodora M. A2 - Klaassen, Curtis D. A2 - Watkins, John B. PY - 2010 T2 - Casarett & Doull's Essentials of Toxicology, 2e AB - The skin participates directly in thermal, electrolyte, hormonal, metabolic, and immune regulation.Percutaneous absorption depends on the xenobiotic's hydrophobicity, which affects its ability to partition into epidermal lipid, and rate of diffusion through this barrier.The cells of the epidermis and pilosebaceous units express biotransformation enzymes.Irritant dermatitis is a nonimmune-related response caused by the direct action of an agent on the skin.Allergic contact dermatitis represents a delayed (type IV) hypersensitivity reaction, whereby minute quantities of material elicit overt reactions. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=6484631 ER -