TY  - CHAP
M1  - Book, Section
TI  - Chapter 12. Biochemical and Metabolic Principles
A1  - Delaney, Kathleen A.
A1  - Kleinschmidt, Kurt C.
A2  - Nelson, Lewis S.
A2  - Lewin, Neal A.
A2  - Howland, Mary Ann
A2  - Hoffman, Robert S.
A2  - Goldfrank, Lewis R.
A2  - Flomenbaum, Neal E.
PY  - 2011
T2  - Goldfrank's Toxicologic Emergencies, 9e
AB  - Xenobiotics  are  compounds  that  are  foreign  to  a  living  system.  Toxic  xenobiotics  interfere  with  critical  metabolic  processes,  causing  structural  damage  to  cells  or  altering  the  cellular  genetic  material.  The  specific  biochemical  sites  of  actions  that  disrupt  metabolic  processes  are  well  characterized  for  many  xenobiotics  although  mechanisms  of  cellular  injury  are  not.  This  chapter  reviews  the  biochemical  principles  that  are  relevant  to  an  understanding  of  the  damaging  effects  of  toxic  xenobiotics  and  the  biotransformation  enzymes  and  their  clinical  implications.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2021/02/28
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=6504103
ER  -