TY  - CHAP
M1  - Book, Section
TI  - Chapter 15. Cyclosporine
A1  - Bauer, Larry A.
A2  - Bauer, Larry A.
PY  - 2008
T2  - Applied Clinical Pharmacokinetics, 2e
AB  - Cyclosporine  is  a  cyclic  polypeptide  with  immunosuppressant  properties  that  is  used  for  the  prevention  of  graft-versus-host  disease  in  hematopoietic  stem  cell  transplantation  patients,  for  the  prevention  of  graft  rejection  in  solid  organ  transplant  patients,  and  for  the  treatment  of  psoriasis,  rheumatoid  arthritis  and  a  variety  of  other  autoimmune  diseases.1,2  The  immunomodulating  properties  of  cyclosporine  are  a  result  of  its  ability  to  block  the  production  of  interleukin-2  and  other  cytokines  secreted  by  T-lymphocytes.3  Cyclosporine  binds  to  cyclophilin,  an  intracellular  cytoplasmic  protein  found  in  T-cells.  The  cyclosporine-cyclophilin  complex  interacts  with  calcineurin,  inhibits  the  catalytic  activity  of  calcineurin,  and  prevents  the  production  of  intermediaries  involved  with  the  expression  of  genes  regulating  the  production  of  cytokines.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/20
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=3517870
ER  -