TY - CHAP M1 - Book, Section TI - Chapter 66. Clinical Toxicology A1 - McCain, Keith R. A1 - Foster, Howell R. A2 - Sutton, S. Scott PY - 2011 T2 - McGraw-Hill's NAPLEX® Review Guide AB - Clinical toxicology involves the assessment and management of disease caused by exposure to an agent(s) in which adverse effects may develop. All natural and synthetic xenobiotics are capable of causing toxicity in humans. It is paramount to recognize that all substances can be poisonous in a specific situation. Paracelsus, the father of modern toxicology, identified this principle in stating that "solely the dose determines that a thing is not a poison.“1 As such, some agents are capable of severe consequence at microgram dose (botulinum toxin) while others are typically viewed as harmless, but at extremes can be lethal (water intoxication).2 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=7256454 ER -