TY  - CHAP
M1  - Book, Section
TI  - Chapter 12. Pharmacogenetics
A1  - Shargel, Leon
A1  - Wu-Pong, Susanna
A1  - Yu, Andrew B.C.
PY  - 2012
T2  - Applied Biopharmaceutics & Pharmacokinetics, 6e
AB  - The  genetic  basis  underlying  variation  in  drug  response  among  individuals  has  become  evident  with  the  introduction  of  modern  analytical  methods  for  the  analysis  of  gene  sequence  and  expression.  The  goal  of  pharmacogenetics  is  to  stratify  drug  therapy  into  groups  of  individual  patients  based  on  their  genetic  makeup.  Additional  factors  such  as  the  environment,  diet,  age,  lifestyle,  and  state  of  health  can  influence  a  person's  response  to  medicine.  An  understanding  of  an  individual's  genetic  makeup  is  thought  to  be  the  key  to  drug  selection,  drug  design,  and  dosage  regimen  development.  Greater  efficacy  and  safety  in  drug  therapy  is  based  on  stratification  of  patients  into  groups  based  on  their  relevant  phenotypes  (Phillips  et  al,  2001;  Mancinelli  et  al,  2000).  Pharmacogenetics  is  the  study  of  the  genetic  basis  of  interindividual  patient  variability  in  the  response  to  drug  therapy.  Pharmacogenetics  allows  for  individualization  of  drug  therapy.  In  contrast,  pharmacokinetics  provides  a  means  for  estimating  kinetic  parameters  of  the  drug  absorption,  distribution,  metabolism,  and  excretion  in  various  population  subgroups  and  then  applying  the  information  to  drug  therapy  for  the  average  patient.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=56604111
ER  -