TY  - CHAP
M1  - Book, Section
TI  - Appendix E: Popular Drugs and Pharmacokinetic Parameters
A1  - Shargel, Leon
A1  - Wu-Pong, Susanna
A1  - Yu, Andrew B.C.
PY  - 2012
T2  - Applied Biopharmaceutics & Pharmacokinetics, 6e
AB  - Table  Graphic  Jump  LocationTable  E-1  Pharmacokinetic  and  Pharmacodynamic  Parameters  for  Selected  DrugsaView  Table||Download  (.pdf)Table  E-1  Pharmacokinetic  and  Pharmacodynamic  Parameters  for  Selected  DrugsaDrugOral  Availability  (%)Urinary  Excretion  (%)Bound  in  Plasma  (%)Clearanceb  (mL/min)Volume  of  Distribution  (L)Half-Life  (h)Effectivec  ConcentrationsToxicc  ConcentrationsAcetaminophen88  ±  153  ±  10350  ±  10067  ±  82.0  ±  0.410–20  μg/mL>300  μg/mLAcyclovirAlendrenate15–300.59  (0.58–0.98)75  ±  1015  ±  4330  ±  8048  ±  132.4  ±  0.7  very  long  (related  to  bone  turnover)Alprazolam88  ±  162071  ±  30.74  ±  0.14  mL/min/kg0.72  ±  0.12  L/Kg12  ±  220–40  ng/mLAlteplase  (TPA)—Low—10  ±  4  mL/min/kg0.1  ±  0.01  L/Kg0.08  ±  0.04Amikacin98491  ±  4219  ±  42.3  ±  0.4Amoxicillin93  ±  1086  ±  818180  ±  2815  ±  21.7  ±  0.3Amphotericin  B2–5>9032  ±  1453  ±  3618  ±  7Ampicillin62  ±  1782  ±  1018  ±  2270  ±  5020  ±  51.3  ±  0.2Aspirind68  ±  31.4  ±  1.249650  ±  8011  ±  20.25  ±  0.3See  salicyclic  acidAtenolol56  ±  3094  ±  8709  μg/mLCephalexin90  ±  991  ±  1814  ±  3300  ±  8018  ±  20.90  ±  0.18Cephalothin5271  ±  3470  ±  12018  ±  80.57  ±  0.32Chloramphenicol75–9025  ±  1553  ±  5170  ±  1466  ±  42.7  ±  0.8Chlordiazepoxided1000.7  μg/mLChloroquined89  ±  1661  ±  461  ±  9750  ±  12013,000  ±  46008.9  ±  3.1  days15–30  ng/mL0.25  μg/mLChlorpropamide>9020  ±  1896  ±  12.1  ±  0.46.8  ±  0.833  ±  6Cimetidine62  ±  662  ±  2019540  ±  13070  ±  141.9  ±  0.30.8  μg/mLCiprofloxacin60  ±  1265  ±  1240420  ±  84130  ±  284.1  ±  0.9Clonidine9562  ±  1120210  ±  84150  ±  3012  ±  70.2–2  ng/mLCyclosporine23.7400  ng/mLDiazepamd1009032  ±  1597  ±  13.9  ±  1.338  ±  106.7  ±  1.7  days>10  ng/mL>35  ng/mLDigoxin70  ±  1360  ±  1125  ±  5130  ±  67440  ±  15039  ±  13>0.8  ng/mL>2  ng/mLDiltiazemd44  ±  108  μg/mLErythromycin35  ±  2512  ±  784  ±  3640  ±  29055  ±  311.6  ±  0.7Erythropoietin7.88  mL/min3.70  L/1.73  m24.92Ethambutol77  ±  879  ±  310  μg/mLEthosuximide—25  ±  1500.19  ±  0.04  mL/min/kg0.72  ±  0.16  L/kg45  ±  840–100  μg/mLFamciclovir77  ±  874  ±  960901  μg/mLIndinavir˜3Indomethacin9815  ±  890140  ±  3018  ±  52.4  ±  0.40.3–3  μg/mL>5  μg/mLLabetalol18  ±  5<5501750  ±  700660  ±  2404.9  ±  2.00.13  μg/mLLidocaine35  ±  112  ±  ...
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=56609197
ER  -