TY - CHAP M1 - Book, Section TI - Chapter 45. Aminoglycosides A1 - Trevor, Anthony J. A1 - Katzung, Bertram G. A1 - Kruidering-Hall, Marieke M. A1 - Masters, Susan B. PY - 2013 T2 - Katzung & Trevor's Pharmacology: Examination & Board Review, 10e AB - In the treatment of microbial infections with antibiotics, multiple daily dosage regimens traditionally have been designed to maintain serum concentrations above the minimal inhibitory concentration (MIC) for as long as possible. However, the in vivo effectiveness of some antibiotics, including aminoglycosides, results from a concentration-dependent killing action. As the plasma level is increased above the MIC, aminoglycosides kill an increasing proportion of bacteria and do so at a more rapid rate. Many antibiotics, including penicillins and cephalosporins, cause time-dependent killing of microorganisms, wherein their in vivo efficacy is directly related to time above MIC and becomes independent of concentration once the MIC has been reached. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=56983841 ER -