TY - CHAP M1 - Book, Section TI - Chapter 48. Antifungal Agents A1 - Trevor, Anthony J. A1 - Katzung, Bertram G. A1 - Kruidering-Hall, Marieke M. A1 - Masters, Susan B. PY - 2013 T2 - Katzung & Trevor's Pharmacology: Examination & Board Review, 10e AB - Fungal infections are difficult to treat, particularly in the immunocompromised or neutropenic patient. Most fungi are resistant to conventional antimicrobial agents, and relatively few drugs are available for the treatment of systemic fungal diseases. Amphotericin B and the azoles (fluconazole, itraconazole, ketoconazole, and voriconazole) are the primary drugs used in systemic infections. They are selectively toxic to fungi because they interact with or inhibit the synthesis of ergosterol, a sterol unique to fungal cell membranes. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=56984056 ER -