TY - CHAP M1 - Book, Section TI - Chapter 45. Pain Management A1 - Scullion, Bridget Fowler A1 - Ryan, Laurajo A2 - Attridge, Rebecca L. A2 - Miller, Monica L. A2 - Moote, Rebecca A2 - Ryan, Laurajo PY - 2013 T2 - Internal Medicine: A Guide to Clinical Therapeutics AB - Pain is a warning mechanism; tissue damage causes release of prostaglandins & other substances that send signals via peripheral nerves (nociceptors) to dorsal horn of spinal cord; from spinal cord, neurotransmitters transmit pain signals to spinothalamic tract & thalamus which process the pain signal in the brain; neurotransmitters (NE, 5HT) & endogenous opioids in brain & spinal cord modulate pain signal SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/16 UR - accesspharmacy.mhmedical.com/content.aspx?aid=57295616 ER -