TY  - CHAP
M1  - Book, Section
TI  - Methemoglobin Inducers
A1  - Price, Dennis P.
A2  - Hoffman, Robert S.
A2  - Howland, Mary Ann
A2  - Lewin, Neal A.
A2  - Nelson, Lewis S.
A2  - Goldfrank, Lewis R.
PY  - 2015
T2  - Goldfrank's Toxicologic Emergencies, 10e
AB  - Methemoglobinemia  is  a  disorder  of  the  red  blood  cell.  Exposure  to  various  xenobiotics  can  adversely  affect  the  red  cell  membrane,  intracellular  metabolism,  and,  as  is  the  case  with  methemoglobinemia,  interfere  with  hemoglobin  function.  Methemoglobin  occurs  when  the  iron  atom  in  hemoglobin  loses  one  electron  to  an  oxidant,  and  the  ferrous  (Fe2+)  or  oxidized  state  of  iron  is  transformed  into  the  ferric  (Fe3+)  state.  Although  methemoglobin  is  always  present  at  low  concentrations  in  the  body,  methemoglobinemia  is  defined  herein  as  an  abnormal  elevation  of  the  methemoglobin  level  above  1%.  The  ubiquity  of  oxidants,  both  in  the  environment  and  in  the  hospital,  has  increased  the  number  of  cases  of  reported  methemoglobinemia.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1108437435
ER  -