TY  - CHAP
M1  - Book, Section
TI  - From Applied Clinical Pharmacokinetics, First Edition
A1  - Bauer, Larry A.
PY  - 2015
T2  - Applied Clinical Pharmacokinetics, 3e
AB  - The  structure  of  this  book  is  uniform  for  each  chapter  and  is  derived  from  my  lectures  in  clinical  pharmacokinetics.  The  introduction,  which  consists  of  a  brief  discussion  of  the  clinical  pharmacology  and  mechanism  of  action  for  the  drug,  is  followed  by  sections  that  describe  the  therapeutic  concentration  range  and  anticipated  adverse  effects  for  the  drug  as  well  as  a  general  monitoring  scheme  for  the  agent.  Clinical  monitoring  parameters  for  therapeutic  response  and  toxicity  and  basic  clinical  pharmacokinetic  parameters  for  the  compound  are  discussed  next.  The  next  sections  describe  the  effects  of  disease  states  and  conditions  on  the  pharmacokinetics  and  dosing  of  the  drug,  and  drug  interactions  that  may  occur  with  concurrent  use  of  other  agents.  Each  chapter  concludes  with  a  comprehensive  presentation  (with  examples)  of  various  methods  to  compute  initial  drug  doses  and  to  modify  drug  therapy  regimens  using  serum  concentrations  to  adjust  doses.  All  dosing  methods  used  in  this  text  are  ones  that  are  published  in  peer-reviewed  literature.  Additionally,  they  are  techniques  that  I  have  personal  clinical  experience  with  and  have  produced  acceptable  results  in  my  practice  and  clinical  clerkships.  Finally,  problems  (with  solutions)  are  included  for  each  chapter  so  that  the  various  dosing  methods  can  be  practiced.  The  problems  are  made  up  of  brief  clinical  vignettes  which,  given  a  brief  background,  request  that  initial  doses  be  computed  or  that  dosage  regimens  be  modified  using  drug  concentrations.  
SN  - 
PB  - McGraw-Hill Medical
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1106302400
ER  -