TY - CHAP M1 - Book, Section TI - Vancomycin A1 - RICCOBONO, DENISE E. A1 - MONTEAGUDO-CHU, MARICELLE O. A2 - Cohen, Henry PY - 2015 T2 - Casebook in Clinical Pharmacokinetics and Drug Dosing AB - Vancomycin is a glycopeptide antibiotic, approved by the FDA in 1958, which is slowly bactericidal against most gram-positive organisms. It is active against Staphylococci (including penicillin- and oxacillin-resistant strains), Streptococci, Enterococci, and other gram-positive organisms. It exerts its bactericidal effect by complexing with the D-alanyl-D-alanine portion of the peptide precursor units on the outer surface of the cell membrane and interferes with cell wall synthesis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1112259650 ER -