TY - CHAP M1 - Book, Section TI - Relationship Between Pharmacokinetics and Pharmacodynamics A1 - Gopalakrishnan, Mathangi A1 - Kumar, Vipul A1 - Issar, Manish A2 - Shargel, Leon A2 - Yu, Andrew B.C. Y1 - 2016 N1 - T2 - Applied Biopharmaceutics & Pharmacokinetics, 7e AB - Quantitatively describe the relationship between drug, receptor, and the pharmacologic response.Explain why the intensity of the pharmacologic response increases with drug concentrations and/or dose up to a maximum response.Explain the difference between an agonist, a partial agonist, and an antagonist.Describe the difference between a reversible and a nonreversible pharmacologic response.Define the term biomarker and explain how biomarkers may be used in the clinical development of drugs.Show how the Emax and sigmoidal Emax model describe the relationship of the pharmacodynamic response to drug concentration.Define the term pharmacokinetic–pharmacodynamic model and provide equations that quantitatively simulates the time course of drug action.Explain the effect compartment in the pharmacodynamic model and name the underlying assumptions.Describe the effect of changing drug dose and/or drug elimination half-life on the duration of drug response.Describe how observed drug tolerance or unusual hysteresis-type drug response may be explained using PD models based on simple drug receptor theory.Define the term drug exposure and explain how it is used to improve drug therapy and safety. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1117901607 ER -