TY - CHAP M1 - Book, Section TI - Ethanol Metabolism A1 - King, Michael W. Y1 - 2014 N1 - T2 - Integrative Medical Biochemistry Examination and Board Review AB - High-Yield TermsAlcohol dehydrogenase (ADH): any of a family of enzymes that catalyze the interconversion of alcohols and aldehydes or ketones; humans express multiple forms of ADH from at least 7 distinct genesAldehyde dehydrogenase (ALDH): any of a family of enzymes that catalyze the oxidation of aldehydes, 2 primary enzymes, ALDH1A1 and ALDH2, involved in metabolizing acetaldehyde generated during ethanol oxidationMicrosomal ethanol-oxidizing system: inducible ethanol-metabolizing system employing a cytochrome P450 enzyme (CYP2E1)Hepatic steatosis: condition of fatty liver that can result from excess alcohol consumptionNonalcoholic fatty liver disease (NAFLD): one cause of a fatty liver (steatosis) not due to excessive alcohol use, most common form of chronic liver disease; obesity and activation of CYP2E1 are major contributors to development of NAFLD and NASHNonalcoholic steatohepatitis (NASH): progression of NAFLD to state of inflammation and fibrosis, the major feature in NASH is fat in the liver, along with inflammation and cellular damage; obesity and activation of CYP2E1 are major contributors to development of NAFLD and NASHKupffer cell: liver resident macrophages that contribute to inflammatory responses in response to increased reactive oxygen species generation during ethanol metabolism SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1122103741 ER -