TY - CHAP M1 - Book, Section TI - Insulin Function A1 - King, Michael W. Y1 - 2014 N1 - T2 - Integrative Medical Biochemistry Examination and Board Review AB - High-Yield TermsIncretin: any gut hormone associated with food intake-stimulation of insulin secretion from the pancreasGlucose-stimulated insulin secretion, GSIS: process of glucose uptake and metabolism by β-cells leading to increased ATP production which inhibits a potassium-dependent ATP (KATP) channel resulting in depolarization of the membrane triggering calcium influx and insulin secretory vesicle fusion with plasma membraneABCC8/KCNJ11: ATP-binding cassette, subfamily C, member 8 (ABCC8-encoded protein is also known as the sulfonylurea receptor, SUR) and potassium inwardly rectifying channel, subfamily J, member 11, protein components of the KATP channel of β-cells that regulates insulin secretionTCF7L2: transcription factor 7-like 2, T-cell–specific HMG-box, involved in Wnt signal transduction, polymorphisms in this gene are the most highly correlated with potential for development of T2DInsulin resistance, IR: a phenomenon whereby binding of insulin to its receptor results in impaired or failed propagation of normal signal transduction events SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1122105485 ER -