TY - CHAP M1 - Book, Section TI - Reactions of Carbonyl Species A1 - Renslo, Adam A2 - Renslo, Adam Y1 - 2016 N1 - T2 - The Organic Chemistry of Medicinal Agents AB - In this chapter we explore the structure and reactivity of the carbonyl (C=O) bond and related carbon–heteroatom (C=X) double bonds. These functional groups are ubiquitous in both biological molecules and in the structures of drugs. A prominent example in biological molecules is the amide bond (peptide bond), which serves as the structural backbone of proteins and also helps determine how proteins fold into the specific three-dimensional shapes that lead to function. Other biological molecules containing ketone or thioester functions are involved in cellular metabolism and in sterol biosynthesis in animals and terpene biosynthesis in plants. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/14 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1124842806 ER -