TY - CHAP M1 - Book, Section TI - Bone and Joint Infections A1 - Honkonen, Marcella N. A1 - Shehab, Ziad A1 - Armstrong, Edward P. A2 - DiPiro, Joseph T. A2 - Talbert, Robert L. A2 - Yee, Gary C. A2 - Matzke, Gary R. A2 - Wells, Barbara G. A2 - Posey, L. Michael Y1 - 2017 N1 - T2 - Pharmacotherapy: A Pathophysiologic Approach, 10e AB - Content UpdateJune 12, 2019Oral versus Intravenous Antibiotics for Bone and Joint Infection: IV antibiotics have long been considered superior to oral antibiotics for serious infections based on the misconception that IV therapy is “stronger” than oral therapy. A recent randomized trial (“Oral versus Intravenous Antibiotics for Bone and Joint Infection”, or “OVIVIA”) found that oral antibiotic therapy was noninferior to IV antibiotic therapy during the first 6 weeks for complex bone and joint infections. The OVIVA trial may impact standard-of-care for bone and joint infections and lessen (or ultimately eliminate) the need for IV antibiotics for 6 weeks in select patients. Using oral therapy in appropriate patients may lead to decreased length of hospital stay, fewer adverse events, fewer IV-related complications, and overall reduced healthcare costs. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1164046683 ER -