TY - CHAP M1 - Book, Section TI - Agents Used in Dyslipidemia A1 - Malloy, Mary J. A1 - Kane, John P. A2 - Katzung, Bertram G. Y1 - 2017 N1 - T2 - Basic & Clinical Pharmacology, 14e AB - CASE STUDYA 42-year-old woman has heterozygous familial hypercholesterolemia (HeFH) but is otherwise well and has no symptoms of coronary or peripheral vascular disease. A carotid ultrasound was normal. Her mother had a myocardial infarction at age 51 and had no known risk factors other than her presumed HeFH. The patient also has elevated lipoprotein (a) at 2.5 times normal and low HDL-C (43 mg/dL). She developed muscle symptoms with each of 3 statins (atorvastatin, rosuvastatin, and simvastatin) so they were discontinued although she did not develop elevated levels of creatine kinase. Her untreated LDL-C is 235 mg/dL and triglycerides 125 mg/dL. Her LDL-C goal for primary prevention of arteriosclerotic vascular disease is in the 70-mg/dL range because of her multiple lipoprotein risk factors and her mother’s history of premature coronary artery disease. She has no other risk factors and her diet and exercise habits are excellent. How would you manage this patient? SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1148438258 ER -