TY - CHAP M1 - Book, Section TI - Enzymes: Regulation of Activities A1 - Kennelly, Peter J. A1 - Rodwell, Victor W. A2 - Rodwell, Victor W. A2 - Bender, David A. A2 - Botham, Kathleen M. A2 - Kennelly, Peter J. A2 - Weil, P. Anthony Y1 - 2018 N1 - T2 - Harper's Illustrated Biochemistry, 31e AB - OBJECTIVESAfter studying this chapter, you should be able to:Explain the concept of whole-body homeostasis.Discuss why the cellular concentrations of substrates for most enzymes tend to be close to Km.List multiple mechanisms by which active control of metabolite flux is achieved.State the advantages of synthesizing certain enzymes as proenzymes.Describe typical structural changes that accompany conversion of a proenzyme to its active form.Indicate two general ways in which an allosteric effector can influence catalytic activity.Outline the roles of protein kinases, protein phosphatases, and of regulatory and hormonal and second messengers in regulating metabolic processes.Explain how the substrate requirements of lysine acetyltransferases and sirtuins can trigger shifts in the degree of lysine acetylation of metabolic enzymes.Describe two ways by which regulatory networks can be constructed in cells. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1160189329 ER -