TY - CHAP M1 - Book, Section TI - Regulation of Gene Expression A1 - Weil, P. Anthony A2 - Rodwell, Victor W. A2 - Bender, David A. A2 - Botham, Kathleen M. A2 - Kennelly, Peter J. A2 - Weil, P. Anthony Y1 - 2018 N1 - T2 - Harper's Illustrated Biochemistry, 31e AB - OBJECTIVESAfter studying this chapter, you should be able to:Explain that the many steps involved in the vectorial processes of gene expression, which range from targeted modulation of gene copy number, to gene rearrangement, to transcription, to mRNA processing and transport from the nucleus, to translation, to protein subcellular compartmentalization, to posttranslational modification and degradation, are all subject to regulatory control, both positive and negative. Changes in any, or multiple of these processes, can increase or decrease the amount and/or activity of the cognate gene product.Appreciate that DNA-binding transcription factors, proteins that bind to specific DNA sequences that are physically linked to their target transcriptional promoter elements, can either activate or repress gene transcription.Recognize that DNA-binding transcription factors are often modular proteins that are composed of structurally and functionally distinct domains, which can directly or indirectly control messenger RNA (mRNA) gene transcription, either through contacts with RNA polymerase and its cofactors, or through interactions with coregulators that modulate nucleosome structure, composition, and position via histone covalent modifications and/or nucleosome displacement.Understand that nucleosome-directed regulatory events typically increase or decrease the accessibility of the underlying DNA such as enhancer or promoter sequences, although nucleosome modification can also create new binding sites for other coregulators.Describe how the processes of gene transcription, RNA processing, and nuclear export of RNA are all coupled. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1160191171 ER -