TY - CHAP M1 - Book, Section TI - Infections Acquired in Health Care Facilities A1 - Weinstein, Robert A. A2 - Jameson, J. Larry A2 - Fauci, Anthony S. A2 - Kasper, Dennis L. A2 - Hauser, Stephen L. A2 - Longo, Dan L. A2 - Loscalzo, Joseph Y1 - 2018 N1 - T2 - Harrison's Principles of Internal Medicine, 20e AB - Health care–associated infections affect as many as 1.7 million patients at a cost of ~$10–33 billion and up to 99,000 lives in U.S. hospitals annually. Although efforts to lower infection risks are challenged by numbers of immunocompromised patients, antibiotic-resistant bacteria, and fungal and viral superinfections, a prevailing viewpoint—”zero tolerance”—is that health care–associated infections are avoidable with strict application of evidence-based prevention guidelines (Table 137-1). In fact, rates of most device-related infections—historically, the largest drivers of risk—have fallen steadily over the past few years. Unfortunately, at the same time, antimicrobial-resistant pathogens have risen in number and are estimated to contribute to ~23,000 deaths annually. This chapter reviews health care–associated and device-related infections as well as basic surveillance, prevention, control, and treatment activities. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1155965658 ER -