TY - CHAP M1 - Book, Section TI - Hirsutism A1 - Ehrmann, David A. A2 - Jameson, J. Larry A2 - Fauci, Anthony S. A2 - Kasper, Dennis L. A2 - Hauser, Stephen L. A2 - Longo, Dan L. A2 - Loscalzo, Joseph Y1 - 2018 N1 - T2 - Harrison's Principles of Internal Medicine, 20e AB - Hirsutism, which is defined as androgen-dependent excessive male-pattern hair growth, affects ~10% of women. Hirsutism is most often idiopathic or the consequence of androgen excess associated with polycystic ovary syndrome (PCOS). Less frequently, it may result from adrenal androgen overproduction as occurs in nonclassic congenital adrenal hyperplasia (CAH) (Table 387-1). Rarely, it is a harbinger of a serious underlying condition. Cutaneous manifestations commonly associated with hirsutism include acne and male-pattern balding (androgenic alopecia). Virilization refers to a condition in which androgen levels are sufficiently high to cause additional signs and symptoms, such as deepening of the voice, breast atrophy, increased muscle bulk, clitoromegaly, and increased libido. Virilization may be due to benign hyperplasia of ovarian theca and stroma cells (e.g., hyperthecosis); it may also result from an ovarian or adrenal neoplasm. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1155955481 ER -