TY  - CHAP
M1  - Book, Section
TI  - Applications of Stem Cell Biology in Clinical Medicine
A1  - Kessler, John A.
A2  - Jameson, J. Larry
A2  - Fauci, Anthony S.
A2  - Kasper, Dennis L.
A2  - Hauser, Stephen L.
A2  - Longo, Dan L.
A2  - Loscalzo, Joseph
Y1  - 2018
N1  - 
T2  - Harrison's Principles of Internal Medicine, 20e
AB  - Damage  to  an  organ  initiates  a  series  of  events  that  lead  to  the  reconstruction  of  the  damaged  tissue,  including  proliferation,  differentiation,  and  migration  of  various  cell  types;  release  of  cytokines  and  chemokines;  and  remodeling  of  the  extracellular  matrix.  Endogenous  stem  and  progenitor  cells  are  among  the  cell  populations  that  are  involved  in  these  injury  responses.  In  normal  steady-state  conditions,  an  equilibrium  is  maintained  in  which  endogenous  stem  cells  intrinsic  to  the  tissue  replenish  dying  cells.  After  tissue  injury,  stem  cells  in  organs  such  as  the  liver  and  skin  have  a  remarkable  ability  to  regenerate  the  organ,  whereas  other  stem  cell  populations,  such  as  those  in  the  heart  and  brain,  have  a  much  more  limited  capability  for  self-repair.  In  rare  circumstances,  circulating  stem  cells  may  contribute  to  regenerative  responses  by  migrating  into  a  tissue  and  differentiating  into  organ-specific  cell  types.  The  goal  of  stem  cell  therapies  is  to  promote  cell  replacement  in  organs  that  are  damaged  beyond  their  ability  to  self-repair.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1156521945
ER  -