TY  - CHAP
M1  - Book, Section
TI  - Microbial Genomics and Infectious Disease
A1  - Bhattacharyya, Roby P.
A1  - Grad, Yonatan H.
A1  - Hung, Deborah T.
A2  - Jameson, J. Larry
A2  - Fauci, Anthony S.
A2  - Kasper, Dennis L.
A2  - Hauser, Stephen L.
A2  - Longo, Dan L.
A2  - Loscalzo, Joseph
Y1  - 2018
N1  - 
T2  - Harrison's Principles of Internal Medicine, 20e
AB  - Just  as  microscopy  opened  up  the  worlds  of  microbiology  by  providing  a  tool  with  which  to  visualize  microorganisms,  technological  advances  in  genomics  are  now  providing  microbiologists  with  powerful  new  methods  to  characterize  the  genetic  map  that  underlies  all  microbes  with  unprecedented  resolution,  thereby  illuminating  their  complex  and  dynamic  interactions  with  each  other,  the  environment,  and  human  health.  The  field  of  infectious  disease  genomics  encompasses  a  vast  frontier  of  active  research  that  is  beginning  to  transform  the  clinical  practice  of  infectious  diseases.  While  genetics  has  long  played  a  key  role  in  elucidating  the  process  of  infection  and  impacting  clinical  infectious  diseases,  the  ability  to  extend  our  thinking  and  our  approaches  beyond  the  study  of  single  genes  to  an  examination  of  the  sequence,  structure,  and  function  of  entire  genomes  is  allowing  us  to  identify  new  possibilities  for  research  and  opportunities  to  change  clinical  practice.  From  the  development  of  diagnostics  with  unprecedented  sensitivity,  specificity,  and  speed  to  the  design  of  novel  public  health  interventions,  technical  and  statistical  genomic  innovations  are  reshaping  our  understanding  of  the  influence  of  the  microbial  world  on  human  health  and  providing  us  with  new  tools  to  diagnose,  track,  and  combat  infection.  In  this  chapter,  we  explore  the  application  of  genomics  methods  to  microbial  pathogens  and  the  infections  they  cause.  We  discuss  innovations  that  are  driving  the  development  of  diagnostic  approaches  as  well  as  the  discovery  of  new  pathogens,  providing  insight  into  novel  therapeutic  approaches  and  paradigms,  and  advancing  methods  in  infectious  disease  epidemiology  and  the  study  of  pathogen  evolution  that  can  inform  infection  control  measures,  public  health  responses  to  outbreaks,  and  vaccine  development.  We  draw  on  examples  in  current  practice  and  from  the  recent  scientific  literature  as  signposts  that  point  toward  ways  in  which  the  insights  from  pathogen  genomics  may  influence  infectious  diseases  in  the  short  and  long  terms.  Table  474-1  provides  definitions  for  a  selection  of  important  terms  used  in  genomics.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/20
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1159157319
ER  -