TY  - CHAP
M1  - Book, Section
TI  - Mechanisms of Toxicity
A1  - Lehman-McKeeman, Lois D.
A2  - Klaassen, Curtis D.
Y1  - 2019
N1  - 
T2  - Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th edition
AB  - Mechanisms  of  toxicity  describe  how  an  adverse  effect  occurs.  Such  events  involve  many  molecular,  biochemical,  and  cellular  processes  that  may  act  in  isolation  or  in  a  complex  combination  to  produce  a  given  response.  Given  the  multitude  of  cells,  organs,  and  pathways  that  underlie  toxic  mechanisms,  it  is  unrealistic  to  discuss  every  possible  mechanism  of  toxicity  in  this  chapter.  Such  detailed  information  is  provided  in  many  of  the  chapters  that  follow,  where  emphasis  is  on  a  specific  organ  and  the  processes  that  render  that  organ  sensitive  or  resistant  to  toxic  insult.  Rather,  the  focus  of  this  chapter  is  to  establish  the  fundamental  concepts  for  how  toxicity  occurs,  to  illustrate  how  to  apply  these  concepts  to  understanding  mechanisms  of  toxicity,  and  to  give  examples  of  mechanisms  of  toxicity.  Mechanistic  toxicology  data  are  also  useful  for  developing  more  predictive  biomarkers  of  toxicity,  developing  approaches  to  antagonize  or  prevent  toxicity,  and  gaining  insight  into  fundamental  physiologic,  biochemical,  and  molecular  processes  that  underlie  normal  and  abnormal  organ  function.  Knowledge  of  mechanisms  of  toxicity  is  also  fundamental  for  developing  risk  assessments  for  chemical  exposure,  as  such  data  are  relevant  to  determining  the  likelihood  that  chemical  exposure  may  cause  harmful  effects.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/24
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1158495955
ER  -